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This study uses OCT imaging to examine morphological changes at the chorioretinal interface of the choroidal melanoma biopsy site over time.

Liverpool Ocular Oncology Centre (LOOC), St. Paul’s Eye Unit, Royal Liverpool University Hospital, Liverpool, United Kingdom.

Retrospective analysis of all patients who underwent 25G vitrector-assisted transretinal biopsy for choroidal melanoma between 1st Jan 2017 and 31st Dec 2019. The biopsy procedure does not involve full vitrectomy, treatment of the retinal hole or tamponade. Patients routinely undergo OCT imaging over the tumour site at each follow up. Cases required a minimum of a baseline OCT and two consecutive post-operative OCT scans of adequate quality, overlying the biopsy site. All images were reviewed and graded by an ophthalmic specialist.

Fifty-one patients met the criteria for inclusion. OCT analysis identified 2 characteristic morphologies following transretinal biopsy –a choroidal plugging of biopsy site (47.0%), or a flat retinal hole (53.0%). Choroidal plugging morphologies tend to remain unchanged over time, whereas flat holes demonstrate greater variability and would more commonly seal over with atrophic retina (Fisher Exact Value = <0.01). 60.8% demonstrated vitreous plugging of the biopsy site.

OCT analysis has identified key morphological changes following transretinal choroidal melanoma biopsy. The morphologies identified may provide dynamic protective effects against vitreous flow into the subretinal space, accounting for low rates of retinal detachment despite the presence of an untreated iatrogenic retinal hole following transretinal biopsy.

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Data utilised for this study are stored on a secure database accessible to treating physicians within the Liverpool Ocular Oncology Centre. Raw, anonymised data are available upon request.

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Liverpool Ocular Oncology Unit, St. Paul’s Eye Unit, Royal Liverpool University Hospital, Liverpool, UK

Shah Haider, Taktak Azam, Gatchalian Leandro, Heimann Heinrich & Hussain Rumana

Department of Medical Physics and Clinical Engineering, Royal Liverpool and Broadgreen University Hospitals NHS Trust, Liverpool, L69 3GA, UK

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HS was responsible for conducting the image assessment after identifying eligible patients, data collection and analyses, interpretation of results, updating reference lists and writing of the manuscript. AT aided in statistical analysis of data. LG reviewed the manuscript and assisted in writing the manuscript. HH contributed to the study design, interpretation of results, updating reference lists, feedback and editing the manuscript. RH contributed to the study design, assessment of image, updating reference lists and interpretation of results feedback and editing of the manuscript.

The authors declare no competing interests.

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Haider, S., Azam, T., Leandro, G. et al. Evaluation of optical coherence tomography (OCT) changes following transretinal tumour biopsy for choroidal melanoma. Eye (2022). https://doi.org/10.1038/s41433-022-02185-1

DOI: https://doi.org/10.1038/s41433-022-02185-1

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Eye (Eye) ISSN 1476-5454 (online) ISSN 0950-222X (print)